Papers › CellViT: Vision Transformers for Precise Cell Segmentation and Classification
CellViT: Vision Transformers for Precise Cell Segmentation and Classification
Fabian Hörst, Moritz Rempe, Lukas Heine, Constantin Seibold, Julius Keyl, Giulia Baldini, Selma Ugurel, Jens Siveke, Barbara Grünwald, Jan Egger, Jens Kleesiek
Nuclei detection and segmentation in hematoxylin and eosin-stained (H&E) tissue images are important clinical tasks and crucial for a wide range of applications. However, it is a challenging task due to nuclei variances in staining and size, overlapping boundaries, and nuclei clustering. While convolutional neural networks have been extensively used for this task, we explore the potential of Transformer-based networks in this domain. Therefore, we introduce a new method for automated instance segmentation of cell nuclei in digitized tissue samples using a deep learning architecture based on Vision Transformer called CellViT. CellViT is trained and evaluated on the PanNuke dataset, which is one of the most challenging nuclei instance segmentation datasets, consisting of nearly 200,000 annotated Nuclei into 5 clinically important classes in 19 tissue types. We demonstrate the superiority of large-scale in-domain and out-of-domain pre-trained Vision Transformers by leveraging the recently published Segment Anything Model and a ViT-encoder pre-trained on 104 million histological image patches - achieving state-of-the-art nuclei detection and instance segmentation performance on the PanNuke dataset with a mean panoptic quality of 0.50 and an F1-detection score of 0.83. The code is publicly available at https://github.com/TIO-IKIM/CellViT
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Tasks
Results from the paper archive 2025-07-28
| Task | Dataset | Model | Metric | Value | Rank at snapshot | Leaderboard | Report |
|---|---|---|---|---|---|---|---|
| Cell Detection | PanNuke | CellViT-SAM-H | Average F1 | 0.83 | #1 of 1 | Archive leaderboard | report |
| Cell Detection | PanNuke | CellViT-SAM-H | Average Precision | 0.84 | #1 of 1 | Archive leaderboard | report |
| Cell Detection | PanNuke | CellViT-SAM-H | Average Recall | 0.81 | #1 of 1 | Archive leaderboard | report |
| Panoptic Segmentation | PanNuke | CellViT-SAM-H | PQ | 50.62 | #2 of 4 | Archive leaderboard | report |
Ranks are positions in the archive's leaderboards as they stood at the 2025-07-28 snapshot. Results published since then are not among these rows, so a rank here is not a current standing.
Methods
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