Papers › Attention based Multiple Instance Learning for Classification of Blood Cell Disorders

Attention based Multiple Instance Learning for Classification of Blood Cell Disorders

22 Jul 2020arXiv:2007.11641archive 2025-07-28

Ario Sadafi, Asya Makhro, Anna Bogdanova, Nassir Navab, Tingying Peng, Shadi Albarqouni, Carsten Marr

Red blood cells are highly deformable and present in various shapes. In blood cell disorders, only a subset of all cells is morphologically altered and relevant for the diagnosis. However, manually labeling of all cells is laborious, complicated and introduces inter-expert variability. We propose an attention based multiple instance learning method to classify blood samples of patients suffering from blood cell disorders. Cells are detected using an R-CNN architecture. With the features extracted for each cell, a multiple instance learning method classifies patient samples into one out of four blood cell disorders. The attention mechanism provides a measure of the contribution of each cell to the overall classification and significantly improves the network's classification accuracy as well as its interpretability for the medical expert.

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ClassificationGeneral ClassificationMultiple Instance Learning

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