Papers › Can Reasoning LLMs Enhance Clinical Document Classification?

Can Reasoning LLMs Enhance Clinical Document Classification?

10 Apr 2025arXiv:2504.08040archive 2025-07-28

Akram Mustafa, Usman Naseem, Mostafa Rahimi Azghadi

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large Language Models (LLMs) offer promising improvements in accuracy and efficiency for this task. This study evaluates the performance and consistency of eight LLMs; four reasoning (Qwen QWQ, Deepseek Reasoner, GPT o3 Mini, Gemini 2.0 Flash Thinking) and four non-reasoning (Llama 3.3, GPT 4o Mini, Gemini 2.0 Flash, Deepseek Chat); in classifying clinical discharge summaries using the MIMIC-IV dataset. Using cTAKES to structure clinical narratives, models were assessed across three experimental runs, with majority voting determining final predictions. Results showed that reasoning models outperformed non-reasoning models in accuracy (71% vs 68%) and F1 score (67% vs 60%), with Gemini 2.0 Flash Thinking achieving the highest accuracy (75%) and F1 score (76%). However, non-reasoning models demonstrated greater stability (91% vs 84% consistency). Performance varied across ICD-10 codes, with reasoning models excelling in complex cases but struggling with abstract categories. Findings indicate a trade-off between accuracy and consistency, suggesting that a hybrid approach could optimise clinical coding. Future research should explore multi-label classification, domain-specific fine-tuning, and ensemble methods to enhance model reliability in real-world applications.

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Classification Document Classification MUlTI-LABEL-ClASSIFICATION Multi-Label Classification

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Adam Attention Attention Dropout BPE Cosine Annealing Dense Connections Discriminative Fine-Tuning Dropout GPT Layer Normalization Linear Layer Linear Warmup With Cosine Annealing Multi-Head Attention Residual Connection Softmax Weight Decay

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