Papers › Vocal markers from sustained phonation in Huntington's Disease

Vocal markers from sustained phonation in Huntington's Disease

9 Jun 2020arXiv:2006.05365archive 2025-07-28

Rachid Riad, Hadrien Titeux, Laurie Lemoine, Justine Montillot, Jennifer Hamet Bagnou, Xuan Nga Cao, Emmanuel Dupoux, Anne-Catherine Bachoud-Lévi

Disease-modifying treatments are currently assessed in neurodegenerative diseases. Huntington's Disease represents a unique opportunity to design automatic sub-clinical markers, even in premanifest gene carriers. We investigated phonatory impairments as potential clinical markers and propose them for both diagnosis and gene carriers follow-up. We used two sets of features: Phonatory features and Modulation Power Spectrum Features. We found that phonation is not sufficient for the identification of sub-clinical disorders of premanifest gene carriers. According to our regression results, Phonatory features are suitable for the predictions of clinical performance in Huntington's Disease.

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