Papers › Universal Transforming Geometric Network

Universal Transforming Geometric Network

2 Aug 2019arXiv:1908.00723archive 2025-07-28

Jin Li

The recurrent geometric network (RGN), the first end-to-end differentiable neural architecture for protein structure prediction, is a competitive alternative to existing models. However, the RGN's use of recurrent neural networks (RNNs) as internal representations results in long training time and unstable gradients. And because of its sequential nature, it is less effective at learning global dependencies among amino acids than existing transformer architectures. We propose the Universal Transforming Geometric Network (UTGN), an end-to-end differentiable model that uses the encoder portion of the Universal Transformer architecture as an alternative for internal representations. Our experiments show that compared to RGN, UTGN achieve a $1.7$ \si{\angstrom} improvement on the free modeling portion and a $0.7$ \si{\angstrom} improvement on the template based modeling of the CASP12 competition.

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Protein Structure Prediction

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Methods

Absolute Position EncodingsAdamAttentionAttention DropoutBPEDense ConnectionsDropoutLabel SmoothingLayer NormalizationLinear LayerMulti-Head AttentionPosition-Wise Feed-Forward LayerReLUResidual ConnectionSoftmaxTransformerUniversal Transformer

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