Papers › Uncertainty quantification in non-rigid image registration via stochastic gradient...
Uncertainty quantification in non-rigid image registration via stochastic gradient Markov chain Monte Carlo
Daniel Grzech, Mohammad Farid Azampour, Huaqi Qiu, Ben Glocker, Bernhard Kainz, Loïc le Folgoc
We develop a new Bayesian model for non-rigid registration of three-dimensional medical images, with a focus on uncertainty quantification. Probabilistic registration of large images with calibrated uncertainty estimates is difficult for both computational and modelling reasons. To address the computational issues, we explore connections between the Markov chain Monte Carlo by backpropagation and the variational inference by backpropagation frameworks, in order to efficiently draw samples from the posterior distribution of transformation parameters. To address the modelling issues, we formulate a Bayesian model for image registration that overcomes the existing barriers when using a dense, high-dimensional, and diffeomorphic transformation parametrisation. This results in improved calibration of uncertainty estimates. We compare the model in terms of both image registration accuracy and uncertainty quantification to VoxelMorph, a state-of-the-art image registration model based on deep learning.
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