Papers › Subgroup Identification using Covariate Adjusted Interaction Trees
Subgroup Identification using Covariate Adjusted Interaction Trees
Jon Arni Steingrimsson, Jiabei Yang
The archive published only this paper's code-link row. Authors, date and abstract are from arXiv's metadata (CC0), read from the Kaggle arXiv metadata snapshot of 2026-09-12 where its title matched the archive's; the title is the archive's.
We consider the problem of identifying sub-groups of participants in a clinical trial that have enhanced treatment effect. Recursive partitioning methods that recursively partition the covariate space based on some measure of between groups treatment effect difference are popular for such sub-group identification. The most commonly used recursive partitioning method, the classification and regression tree algorithm, first creates a large tree by recursively partitioning the covariate space using some splitting criteria and then selects the final tree from all subtrees of the large tree. In the context of subgroup identification, calculation of the splitting criteria and the evaluation measure used for final tree selection rely on comparing differences in means between the treatment and control arm. When covariates are prognostic for the outcome, covariate adjusted estimators have the ability to improve efficiency compared to using differences in means between the treatment and control group. This manuscript develops two covariate adjusted estimators that can be used to both make splitting decisions and for final tree selection. The performance of the resulting covariate adjusted recursive partitioning algorithm is evaluated using simulations and by analyzing a clinical trial that evaluates if motivational interviews improve treatment engagement for substance abusers.
Code
Repository list and official/mentioned flags are the archive's, frozen 2025-07-28. Reachability, where shown, is from one Syntology probe window (2026-09-16 to 2026-09-18); repositories not probed show nothing. GitHub stars are not tracked.
Code Syntology ran Syntology
Not run by Syntology. Nothing on this page verifies that the listed code works.
Results from the paper archive 2025-07-28
No leaderboard rows for this paper in the archive.
Report a problem or propose a change · a person checks every report against the paper or source before anything changes; decisions are listed on /corrections