Papers › Stereotypical escape behavior in Caenorhabditis elegans allows quantification of...
Stereotypical escape behavior in Caenorhabditis elegans allows quantification of nociceptive stimuli levels
Kawai Leung, Aylia Mohammadi, William S. Ryu, Ilya Nemenman
The archive published only this paper's code-link row. Authors, date and abstract are from arXiv's metadata (CC0), read from the Kaggle arXiv metadata snapshot of 2026-09-12 where its title matched the archive's; the title is the archive's.
Experiments of pain with human subjects are difficult, subjective, and ethically constrained. Since the molecular mechanisms of pain transduction are reasonably conserved among different species, these problems are partially solved by the use of animal models. However, animals cannot easily communicate to us their own pain levels. Thus progress depends crucially on our ability to quantitatively and objectively infer the perceived level of noxious stimuli from the behavior of animals. Here we develop a quantitative model to infer the perceived level of thermal nociception from the stereotyped nociceptive response of individual nematodes Caenorhabditis elegans stimulated by an IR laser. The model provides a method for quantification of analgesic effects of chemical stimuli or genetic mutations in C. elegans. We test the nociception of ibuprofen-treated worms and a TRPV (transient receptor potential) mutant, and we show that the perception of thermal nociception for the ibuprofen treated worms is lower than the wild-type. At the same time, our model shows that the mutant changes the worm's behavior beyond affecting nociception. Finally, we determine the stimulus level that best distinguishes the analgesic effects and the minimum number of worms that allow for a statistically significant identification of these effects.
Code
Repository list and official/mentioned flags are the archive's, frozen 2025-07-28. Reachability, where shown, is from one Syntology probe window (2026-09-16 to 2026-09-18); repositories not probed show nothing. GitHub stars are not tracked.
Code Syntology ran Syntology
Not run by Syntology. Nothing on this page verifies that the listed code works.
Results from the paper archive 2025-07-28
No leaderboard rows for this paper in the archive.
Report a problem or propose a change · a person checks every report against the paper or source before anything changes; decisions are listed on /corrections