Papers › plmmr: an R package to fit penalized linear mixed models for genome-wide association...

plmmr: an R package to fit penalized linear mixed models for genome-wide association data with complex correlation structure

3 Feb 2025arXiv:2502.01577links table onlyarchive 2025-07-28

Tabitha K. Peter, Anna C. Reisetter, Yujing Lu, Oscar A. Rysavy, Patrick J. Breheny

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Correlation among the observations in high-dimensional regression modeling can be a major source of confounding. We present a new open-source package, plmmr, to implement penalized linear mixed models in R. This R package estimates correlation among observations in high-dimensional data and uses those estimates to improve prediction with the best linear unbiased predictor. The package uses memory-mapping so that genome-scale data can be analyzed on ordinary machines even if the size of data exceeds RAM. We present here the methods, workflow, and file-backing approach upon which plmmr is built, and we demonstrate its computational capabilities with two examples from real GWAS data.

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