Papers › Pathological Evidence Exploration in Deep Retinal Image Diagnosis

Pathological Evidence Exploration in Deep Retinal Image Diagnosis

6 Dec 2018arXiv:1812.02640archive 2025-07-28

Yuhao Niu, Lin Gu, Feng Lu, Feifan Lv, Zongji Wang, Imari Sato, Zijian Zhang, Yangyan Xiao, Xunzhang Dai, Tingting Cheng

Though deep learning has shown successful performance in classifying the label and severity stage of certain disease, most of them give few evidence on how to make prediction. Here, we propose to exploit the interpretability of deep learning application in medical diagnosis. Inspired by Koch's Postulates, a well-known strategy in medical research to identify the property of pathogen, we define a pathological descriptor that can be extracted from the activated neurons of a diabetic retinopathy detector. To visualize the symptom and feature encoded in this descriptor, we propose a GAN based method to synthesize pathological retinal image given the descriptor and a binary vessel segmentation. Besides, with this descriptor, we can arbitrarily manipulate the position and quantity of lesions. As verified by a panel of 5 licensed ophthalmologists, our synthesized images carry the symptoms that are directly related to diabetic retinopathy diagnosis. The panel survey also shows that our generated images is both qualitatively and quantitatively superior to existing methods.

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