Papers › OpenMM-Python-Force: Deploying Accelerated Python Modules in Molecular Dynamics Simulation

OpenMM-Python-Force: Deploying Accelerated Python Modules in Molecular Dynamics Simulation

24 Dec 2024arXiv:2412.18271links table onlyarchive 2025-07-28

Zhi Wang, Wen Yan

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We present OpenMM-Python-Force, a plugin designed to extend OpenMM's functionality by enabling integration of energy and force calculations from external Python programs via a callback mechanism. During molecular dynamics simulations, data exchange can be implemented through torch.Tensor or numpy.ndarray, depending on the specific use case. This enhancement significantly expands OpenMM's capabilities, facilitating seamless integration of accelerated Python modules within molecular dynamics simulations. This approach represents a general solution that can be adapted to other molecular dynamics engines beyond OpenMM. The source code is openly available at https://github.com/bytedance/OpenMM-Python-Force.

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