Papers › New strategies to improve minimap2 alignment accuracy

New strategies to improve minimap2 alignment accuracy

7 Aug 2021arXiv:2108.03515archive 2025-07-28

Heng Li

Summary: We present several recent improvements to minimap2, a versatile pairwise aligner for nucleotide sequences. Now minimap2 v2.22 can more accurately map long reads to highly repetitive regions and align through insertions or deletions up to 100kb by default, addressing major weakness in minimap2 v2.18 or earlier. Availability and implementation: https://github.com/lh3/minimap2

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