Papers › Medical Image Synthesis with Deep Convolutional Adversarial Networks
Medical Image Synthesis with Deep Convolutional Adversarial Networks
Dong Nie, Roger Trullo, Jun Lian, Li Wang, Caroline Petitjean, Su Ruan, Qian Wang, and Dinggang Shen, Fellow, IEEE
Medical imaging plays a critical role in various clinical applications. However, due to multiple considera- tions such as cost and radiation dose, the acquisition of certain image modalities may be limited. Thus, medical im- age synthesis can be of great benefit by estimating a de- sired imaging modality without incurring an actual scan. In this paper, we propose a generative adversarial approach to address this challenging problem. Specifically, we train a fully convolutional network (FCN) to generate a target image given a source image. To better model a nonlinear mapping from source to target and to produce more realistic target images, we propose to use the adversarial learning strategy to better model the FCN. Moreover, the FCN is designed to incorporate an image-gradient-difference-based loss func- tion to avoid generating blurry target images. Long-term residual unit is also explored to help the training of the net- work. We further apply Auto-Context Model to implement a context-aware deep convolutional adversarial network. Ex- perimental results show that our method is accurate and robust for synthesizing target images from the correspond- ing source images. In particular, we evaluate our method on three datasets, to address the tasks of generating CT from MRI and generating 7T MRI from3T MRI images. Our method outperforms the state-of-the-art methods under comparison in all datasets and tasks. Index Terms—Adversarial learning, auto-context model, deep learning, image synthesis, residual learning. I.
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