Papers › Nonequilibrium antigen recognition during infections and vaccinations
Nonequilibrium antigen recognition during infections and vaccinations
Roberto Morán-Tovar, Michael Lässig
The immune response to an acute primary infection is a coupled process of antigen proliferation, molecular recognition by naive B cells, and their subsequent proliferation and antibody shedding. This process contains a fundamental problem: the recognition of an exponentially time-dependent antigen signal. Here we show that B cells can efficiently recognise new antigens by a tuned kinetic proofreading mechanism, where the molecular recognition machinery is adapted to the complexity of the immune repertoire. This process produces potent, specific and fast recognition of antigens, maintaining a spectrum of genetically distinct B cell lineages as input for affinity maturation. We show that the proliferation-recognition dynamics of a primary infection is a generalised Luria-Delbr\"uck process, akin to the dynamics of the classic fluctuation experiment. This map establishes a link between signal recognition dynamics and evolution. We derive the resulting statistics of the activated immune repertoire: antigen binding affinity, expected size, and frequency of active B cell clones are related by power laws, which define the class of generalised Luria-Delbr\"uck processes. Their exponents depend on the antigen and B cell proliferation rate, the number of proofreading steps, and the lineage density of the naive repertoire. We extend the model to include spatio-temporal processes, including the diffusion-recognition dynamics of a vaccination. Empirical data of activated mouse immune repertoires are found to be consistent with activation involving about three proofreading steps. The model predicts key clinical characteristics of acute infections and vaccinations, including the emergence of elite neutralisers and the effects of immune ageing. More broadly, our results establish infections and vaccinations as a new probe into the global architecture and functional principles of immune repertoires.
Code
Repository list and official/mentioned flags are the archive's, frozen 2025-07-28. Reachability, where shown, is from one Syntology probe window (2026-09-16 to 2026-09-18); repositories not probed show nothing. GitHub stars are not tracked.
Code Syntology ran Syntology
Not run by Syntology. Nothing on this page verifies that the listed code works.
Results from the paper archive 2025-07-28
No leaderboard rows for this paper in the archive.
Methods
Report a problem or propose a change · a person checks every report against the paper or source before anything changes; decisions are listed on /corrections