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Identifying heterogeneous micromechanical properties of biological tissues via physics-informed neural networks
Wensi Wu, Mitchell Daneker, Kevin T. Turner, Matthew A. Jolley, Lu Lu
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The heterogeneous micromechanical properties of biological tissues have profound implications across diverse medical and engineering domains. However, identifying full-field heterogeneous elastic properties of soft materials using traditional engineering approaches is fundamentally challenging due to difficulties in estimating local stress fields. Recently, there has been a growing interest in using data-driven models to learn full-field mechanical responses such as displacement and strain from experimental or synthetic data. However, research studies on inferring full-field elastic properties of materials, a more challenging problem, are scarce, particularly for large deformation, hyperelastic materials. Here, we propose a physics-informed machine learning approach to identify the elasticity map in nonlinear, large deformation hyperelastic materials. We evaluate the prediction accuracies and computational efficiency of physics-informed neural networks (PINNs) by inferring the heterogeneous elasticity maps across three materials with structural complexity that closely resemble real tissue patterns, such as brain tissue and tricuspid valve tissue. We further applied our improved architecture to three additional examples of breast cancer tissue and extended our analysis to three hyperelastic constitutive models: Neo-Hookean, Mooney Rivlin, and Gent. Our selected network architecture consistently produced highly accurate estimations of heterogeneous elasticity maps, even when there was up to 10% noise present in the training data.
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