Papers › Heterogenous Ensemble of Models for Molecular Property Prediction

Heterogenous Ensemble of Models for Molecular Property Prediction

20 Nov 2022arXiv:2211.11035archive 2025-07-28

Sajad Darabi, Shayan Fazeli, Jiwei Liu, Alexandre Milesi, Pawel Morkisz, Jean-François Puget, Gilberto Titericz

Previous works have demonstrated the importance of considering different modalities on molecules, each of which provide a varied granularity of information for downstream property prediction tasks. Our method combines variants of the recent TransformerM architecture with Transformer, GNN, and ResNet backbone architectures. Models are trained on the 2D data, 3D data, and image modalities of molecular graphs. We ensemble these models with a HuberRegressor. The models are trained on 4 different train/validation splits of the original train + valid datasets. This yields a winning solution to the 2\textsuperscript{nd} edition of the OGB Large-Scale Challenge (2022) on the PCQM4Mv2 molecular property prediction dataset. Our proposed method achieves a test-challenge MAE of $0.0723$ and a validation MAE of $0.07145$. Total inference time for our solution is less than 2 hours. We open-source our code at https://github.com/jfpuget/NVIDIA-PCQM4Mv2.

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Molecular Property PredictionPredictionProperty Prediction

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1x1 ConvolutionAbsolute Position EncodingsAdamAttentionAverage PoolingBPEBatch NormalizationBottleneck Residual BlockConvolutionDense ConnectionsDropoutGlobal Average PoolingKaiming InitializationLabel SmoothingLayer NormalizationLinear LayerMAEMax PoolingMulti-Head AttentionPosition-Wise Feed-Forward LayerReLUResidual BlockResidual ConnectionSoftmaxTransformer

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