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Gray Matter Segmentation in Ultra High Resolution 7 Tesla ex vivo T2w MRI of Human Brain Hemispheres
Pulkit Khandelwal, Shokufeh Sadaghiani, Michael Tran Duong, Sadhana Ravikumar, Sydney Lim, Sanaz Arezoumandan, Claire Peterson, Eunice Chung, Madigan Bedard, Noah Capp, Ranjit Ittyerah, Elyse Migdal, Grace Choi, Emily Kopp, Bridget Loja, Eusha Hasan, Jiacheng Li, Karthik Prabhakaran, Gabor Mizsei, Marianna Gabrielyan, Theresa Schuck, John Robinson, Daniel Ohm, Edward Lee, John Q. Trojanowski, Corey McMillan, Murray Grossman, David Irwin, M. Dylan Tisdall, Sandhitsu R. Das, Laura E. M. Wisse, David A. Wolk, Paul A. Yushkevich
Ex vivo MRI of the brain provides remarkable advantages over in vivo MRI for visualizing and characterizing detailed neuroanatomy. However, automated cortical segmentation methods in ex vivo MRI are not well developed, primarily due to limited availability of labeled datasets, and heterogeneity in scanner hardware and acquisition protocols. In this work, we present a high resolution 7 Tesla dataset of 32 ex vivo human brain specimens. We benchmark the cortical mantle segmentation performance of nine neural network architectures, trained and evaluated using manually-segmented 3D patches sampled from specific cortical regions, and show excellent generalizing capabilities across whole brain hemispheres in different specimens, and also on unseen images acquired at different magnetic field strength and imaging sequences. Finally, we provide cortical thickness measurements across key regions in 3D ex vivo human brain images. Our code and processed datasets are publicly available at https://github.com/Pulkit-Khandelwal/picsl-ex-vivo-segmentation.
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