Papers › Generalizable synthetic MRI with physics-informed convolutional networks
Generalizable synthetic MRI with physics-informed convolutional networks
Luuk Jacobs, Stefano Mandija, Hongyan Liu, Cornelis A. T. van den Berg, Alessandro Sbrizzi, Matteo Maspero
In this study, we develop a physics-informed deep learning-based method to synthesize multiple brain magnetic resonance imaging (MRI) contrasts from a single five-minute acquisition and investigate its ability to generalize to arbitrary contrasts to accelerate neuroimaging protocols. A dataset of fifty-five subjects acquired with a standard MRI protocol and a five-minute transient-state sequence was used to develop a physics-informed deep learning-based method. The model, based on a generative adversarial network, maps data acquired from the five-minute scan to "effective" quantitative parameter maps, here named q*-maps, by using its generated PD, T1, and T2 values in a signal model to synthesize four standard contrasts (proton density-weighted, T1-weighted, T2-weighted, and T2-weighted fluid-attenuated inversion recovery), from which losses are computed. The q*-maps are compared to literature values and the synthetic contrasts are compared to an end-to-end deep learning-based method proposed by literature. The generalizability of the proposed method is investigated for five volunteers by synthesizing three non-standard contrasts unseen during training and comparing these to respective ground truth acquisitions via contrast-to-noise ratio and quantitative assessment. The physics-informed method was able to match the high-quality synthMRI of the end-to-end method for the four standard contrasts, with mean \pm standard deviation structural similarity metrics above 0.75 \pm 0.08 and peak signal-to-noise ratios above 22.4 \pm 1.9 and 22.6 \pm 2.1. Additionally, the physics-informed method provided retrospective contrast adjustment, with visually similar signal contrast and comparable contrast-to-noise ratios to the ground truth acquisitions for three sequences unused for model training, demonstrating its generalizability and potential application to accelerate neuroimaging protocols.
Code
Repository list and official/mentioned flags are the archive's, frozen 2025-07-28. Reachability, where shown, is from one Syntology probe window (2026-09-16 to 2026-09-18); repositories not probed show nothing. GitHub stars are not tracked.
Code Syntology ran Syntology
Not run by Syntology. Nothing on this page verifies that the listed code works.
Results from the paper archive 2025-07-28
No leaderboard rows for this paper in the archive.
Report a problem or propose a change · a person checks every report against the paper or source before anything changes; decisions are listed on /corrections