Papers › Generalised Bayesian distance-based phylogenetics for the genomics era
Generalised Bayesian distance-based phylogenetics for the genomics era
Matthew J. Penn, Neil Scheidwasser, Mark P. Khurana, Christl A. Donnelly, David A. Duchêne, Samir Bhatt
As whole genomes become widely available, maximum likelihood and Bayesian phylogenetic methods are demonstrating their limits in meeting the escalating computational demands. Conversely, distance-based phylogenetic methods are efficient, but are rarely favoured due to their inferior performance. Here, we extend distance-based phylogenetics using an entropy-based likelihood of the evolution among pairs of taxa, allowing for fast Bayesian inference in genome-scale datasets. We provide evidence of a close link between the inference criteria used in distance methods and Felsenstein's likelihood, such that the methods are expected to have comparable performance in practice. Using the entropic likelihood, we perform Bayesian inference on three phylogenetic benchmark datasets and find that estimates closely correspond with previous inferences. We also apply this rapid inference approach to a 60-million-site alignment from 363 avian taxa, covering most avian families. The method has outstanding performance and reveals substantial uncertainty in the avian diversification events immediately after the K-Pg transition event. The entropic likelihood allows for efficient Bayesian phylogenetic inference, accommodating the analysis demands of the genomic era.
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