Papers › Evolutionary accumulation modelling in AMR: machine learning to infer and predict...
Evolutionary accumulation modelling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance
Jessica Renz, Kazeem A. Dauda, Olav N. L. Aga, Ramon Diaz-Uriarte, Iren H. Löhr, Bjørn Blomberg, Iain G. Johnston
Can we understand and predict the evolutionary pathways by which bacteria acquire multi-drug resistance (MDR)? These questions have substantial potential impact in basic biology and in applied approaches to address the global health challenge of antimicrobial resistance (AMR). Here, we review how a class of machine learning approaches called evolutionary accumulation modelling (EvAM) may help reveal these dynamics using genetic and/or phenotypic AMR datasets, without requiring longitudinal sampling. These approaches are well-established in cancer progression and evolutionary biology, but currently less used in AMR research. We discuss how EvAM can learn the evolutionary pathways by which drug resistances and AMR features are acquired as pathogens evolve, predict next evolutionary steps, identify influences between AMR features, and explore differences in MDR evolution between regions, demographics, and more. We demonstrate a case study on MDR evolution in Mycobacterium tuberculosis and discuss the strengths and weaknesses of these approaches, providing links to some approaches for implementation.
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