Papers › DeepCEL0 for 2D Single Molecule Localization in Fluorescence Microscopy
DeepCEL0 for 2D Single Molecule Localization in Fluorescence Microscopy
Pasquale Cascarano, Maria Colomba Comes, Andrea Sebastiani, Arianna Mencattini, Elena Loli Piccolomini, Eugenio Martinelli
In fluorescence microscopy, Single Molecule Localization Microscopy (SMLM) techniques aim at localizing with high precision high density fluorescent molecules by stochastically activating and imaging small subsets of blinking emitters. Super Resolution (SR) plays an important role in this field since it allows to go beyond the intrinsic light diffraction limit. In this work, we propose a deep learning-based algorithm for precise molecule localization of high density frames acquired by SMLM techniques whose ℓ₂-based loss function is regularized by positivity and ℓ₀-based constraints. The ℓ₀ is relaxed through its Continuous Exact ℓ₀ (CEL0) counterpart. The arising approach, named DeepCEL0, is parameter-free, more flexible, faster and provides more precise molecule localization maps if compared to the other state-of-the-art methods. We validate our approach on both simulated and real fluorescence microscopy data.
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