Papers › ClinicalMamba: A Generative Clinical Language Model on Longitudinal Clinical Notes

ClinicalMamba: A Generative Clinical Language Model on Longitudinal Clinical Notes

9 Mar 2024arXiv:2403.05795archive 2025-07-28

Zhichao Yang, Avijit Mitra, Sunjae Kwon, Hong Yu

The advancement of natural language processing (NLP) systems in healthcare hinges on language model ability to interpret the intricate information contained within clinical notes. This process often requires integrating information from various time points in a patient's medical history. However, most earlier clinical language models were pretrained with a context length limited to roughly one clinical document. In this study, We introduce ClinicalMamba, a specialized version of the Mamba language model, pretrained on a vast corpus of longitudinal clinical notes to address the unique linguistic characteristics and information processing needs of the medical domain. ClinicalMamba, with 130 million and 2.8 billion parameters, demonstrates a superior performance in modeling clinical language across extended text lengths compared to Mamba and clinical Llama. With few-shot learning, ClinicalMamba achieves notable benchmarks in speed and accuracy, outperforming existing clinical language models and general domain large models like GPT-4 in longitudinal clinical notes information extraction tasks.

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Tasks

Few-Shot LearningLanguage ModelingLanguage ModellingMamba

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Methods

Absolute Position EncodingsAdamAttentionBPEDense ConnectionsDropoutGPT-4Label SmoothingLayer NormalizationLinear LayerMulti-Head AttentionPosition-Wise Feed-Forward LayerResidual ConnectionSPEEDSoftmaxTransformer

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