Papers › Assessing Pattern Recognition Performance of Neuronal Cultures through Accurate Simulation
Assessing Pattern Recognition Performance of Neuronal Cultures through Accurate Simulation
Gabriele Lagani, Raffaele Mazziotti, Fabrizio Falchi, Claudio Gennaro, Guido Marco Cicchini, Tommaso Pizzorusso, Federico Cremisi, Giuseppe Amato
Previous work has shown that it is possible to train neuronal cultures on Multi-Electrode Arrays (MEAs), to recognize very simple patterns. However, this work was mainly focused to demonstrate that it is possible to induce plasticity in cultures, rather than performing a rigorous assessment of their pattern recognition performance. In this paper, we address this gap by developing a methodology that allows us to assess the performance of neuronal cultures on a learning task. Specifically, we propose a digital model of the real cultured neuronal networks; we identify biologically plausible simulation parameters that allow us to reliably reproduce the behavior of real cultures; we use the simulated culture to perform handwritten digit recognition and rigorously evaluate its performance; we also show that it is possible to find improved simulation parameters for the specific task, which can guide the creation of real cultures.
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