Papers › AMICI: High-Performance Sensitivity Analysis for Large Ordinary Differential Equation Models

AMICI: High-Performance Sensitivity Analysis for Large Ordinary Differential Equation Models

16 Dec 2020arXiv:2012.09122archive 2025-07-28

Fabian Fröhlich, Daniel Weindl, Yannik Schälte, Dilan Pathirana, Łukasz Paszkowski, Glenn Terje Lines, Paul Stapor, Jan Hasenauer

Ordinary differential equation models facilitate the understanding of cellular signal transduction and other biological processes. However, for large and comprehensive models, the computational cost of simulating or calibrating can be limiting. AMICI is a modular toolbox implemented in C++/Python/MATLAB that provides efficient simulation and sensitivity analysis routines tailored for scalable, gradient-based parameter estimation and uncertainty quantification. AMICI is published under the permissive BSD-3-Clause license with source code publicly available on https://github.com/AMICI-dev/AMICI. Citeable releases are archived on Zenodo.

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SensitivityUncertainty QuantificationVocal Bursts Intensity Predictionparameter estimation

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