Papers › Algebraic framework for determining laminar pattern bifurcations by lateral-inhibition...
Algebraic framework for determining laminar pattern bifurcations by lateral-inhibition in 2D and 3D bilayer geometries
Joshua W. Moore, Trevor C. Dale, Thomas E. Woolley
The archive published only this paper's code-link row. Authors, date and abstract are from arXiv's metadata (CC0), read from the Kaggle arXiv metadata snapshot of 2026-09-12 where its title matched the archive's; the title is the archive's.
Fine-grain patterns produced by juxtacrine signalling, have been studied using static monolayers as cellular domains. Unfortunately, analytical results are restricted to a few cells due to the algebraic complexity of nonlinear dynamical systems. Motivated by concentric patterning of Notch expression observed in the mammary gland, we combine concepts from graph and control theory to represent cellular connectivity. The resulting theoretical framework allows us to exploit the symmetry of multicellular bilayer structures in 2D and 3D, thereby deriving analytical conditions that drive the dynamical system to form laminar patterns consistent with the formulation of cell polarity. Critically, the conditions are independent of the precise dynamical details, thus the framework allows for the utmost generality in understanding the influence of cellular geometry on patterning in lateral-inhibition systems. Applying the analytic conditions to mammary organoids suggests that intense cell signalling polarity is required for the maintenance of stratified cell-types within a static bilayer using a lateral-inhibition mechanism. Furthermore, by employing 2D and 3D cell-based models, we highlight that the cellular polarity conditions derived from static domains have the capacity to generate laminar patterning in dynamic environments. However, they are insufficient for the maintenance of patterning when subjected to substantial morphological perturbations. In agreement with the mathematical implications of strict signalling polarity induced on the cells, we propose an adhesion dependent Notch-Delta biological process which has the potential to initiate bilayer stratification in a developing mammary organoid.
Code
Repository list and official/mentioned flags are the archive's, frozen 2025-07-28. Reachability, where shown, is from one Syntology probe window (2026-09-16 to 2026-09-18); repositories not probed show nothing. GitHub stars are not tracked.
Code Syntology ran Syntology
Not run by Syntology. Nothing on this page verifies that the listed code works.
Results from the paper archive 2025-07-28
No leaderboard rows for this paper in the archive.
Report a problem or propose a change · a person checks every report against the paper or source before anything changes; decisions are listed on /corrections