Papers › A zero-inflated endemic-epidemic model with an application to measles time series in Germany

A zero-inflated endemic-epidemic model with an application to measles time series in Germany

18 Jan 2022arXiv:2201.07285links table onlyarchive 2025-07-28

Junyi Lu, Sebastian Meyer

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Count data with excessive zeros are often encountered when modelling infectious disease occurrence. The degree of zero inflation can vary over time due to non-epidemic periods as well as by age group or region. The existing endemic-epidemic modelling framework (aka HHH) lacks a proper treatment for surveillance data with excessive zeros as it is limited to Poisson and negative binomial distributions. In this paper, we propose a multivariate zero-inflated endemic-epidemic model with random effects to extend HHH. Parameters of the new zero-inflation and the HHH part of the model can be estimated jointly and efficiently via (penalized) maximum likelihood inference using analytical derivatives. A simulation study confirms proper convergence and coverage probabilities of confidence intervals. Applying the model to measles counts in the 16 German states, 2005--2018, shows that the added zero-inflation improves probabilistic forecasts.

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