Papers › A fast and convergent combined Newton and gradient descent method for computing steady...
A fast and convergent combined Newton and gradient descent method for computing steady states of chemical reaction networks
Silvia Berra, Alessandro La Torraca, Federico Benvenuto, Sara Sommariva
The archive published only this paper's code-link row. Authors, date and abstract are from arXiv's metadata (CC0), read from the Kaggle arXiv metadata snapshot of 2026-09-12 where its title matched the archive's; the title is the archive's.
In this work we present a fast, globally convergent, iterative algorithm for computing the asymptotically stable states of nonlinear large--scale systems of quadratic autonomous Ordinary Differential Equations (ODEs) modeling, e.g., the dynamic of complex chemical reaction networks. Towards this aim, we reformulate the problem as a box--constrained optimization problem where the roots of a set of nonlinear equations need to be determined. Then, we propose to use a projected Newton's approach combined with a gradient descent algorithm so that every limit point of the sequence generated by the overall algorithm is a stationary point. More importantly, we suggest replacing the standard orthogonal projector with a novel operator that ensures the final solution to satisfy the box constraints while lowering the probability that the intermediate points reached at each iteration belong to the boundary of the box where the Jacobian of the objective function may be singular. The effectiveness of the proposed approach is shown in a practical scenario concerning a chemical reaction network modeling the signaling network of colorectal cancer cells. Specifically, in this scenario the proposed algorithm is proven to be faster and more accurate than a classical dynamical approach where the asymptotically stable states are computed as the limit points of the flux of the Cauchy problem associated with the ODEs system.
Code
Repository list and official/mentioned flags are the archive's, frozen 2025-07-28. Reachability, where shown, is from one Syntology probe window (2026-09-16 to 2026-09-18); repositories not probed show nothing. GitHub stars are not tracked.
Code Syntology ran Syntology
Not run by Syntology. Nothing on this page verifies that the listed code works.
Results from the paper archive 2025-07-28
No leaderboard rows for this paper in the archive.
Report a problem or propose a change · a person checks every report against the paper or source before anything changes; decisions are listed on /corrections