{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/unsupervised-multi-modal-medical-image","title":"Unsupervised Multi-Modal Medical Image Registration via Discriminator-Free Image-to-Image Translation","arxiv_id":"2204.13656","date":"2022-04-28","proceeding":null,"authors":["Zekang Chen","Jia Wei","Rui Li"],"abstract":"In clinical practice, well-aligned multi-modal images, such as Magnetic Resonance (MR) and Computed Tomography (CT), together can provide complementary information for image-guided therapies. Multi-modal image registration is essential for the accurate alignment of these multi-modal images. However, it remains a very challenging task due to complicated and unknown spatial correspondence between different modalities. In this paper, we propose a novel translation-based unsupervised deformable image registration approach to convert the multi-modal registration problem to a mono-modal one. Specifically, our approach incorporates a discriminator-free translation network to facilitate the training of the registration network and a patchwise contrastive loss to encourage the translation network to preserve object shapes. Furthermore, we propose to replace an adversarial loss, that is widely used in previous multi-modal image registration methods, with a pixel loss in order to integrate the output of translation into the target modality. This leads to an unsupervised method requiring no ground-truth deformation or pairs of aligned images for training. We evaluate four variants of our approach on the public Learn2Reg 2021 datasets \\cite{hering2021learn2reg}. The experimental results demonstrate that the proposed architecture achieves state-of-the-art performance. Our code is available at https://github.com/heyblackC/DFMIR.","url_abs":"https://arxiv.org/abs/2204.13656v1","url_pdf":"https://arxiv.org/pdf/2204.13656v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"unsupervised-multi-modal-medical-image","repo_url":"https://github.com/heyblackC/DFMIR","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"computed-tomography-ct","task_name":"Computed Tomography (CT)"},{"task_slug":"image-registration","task_name":"Image Registration"},{"task_slug":"image-to-image-translation","task_name":"Image-to-Image Translation"},{"task_slug":"medical-image-registration","task_name":"Medical Image Registration"},{"task_slug":"translation","task_name":"Translation"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":"https://app.syntology.ai/?focus=2204.13656","mcp":{"get_harvested_code_for_paper":{"arxiv_id":"2204.13656"}},"developers":"https://syntology.ai/developers","read_at":"2026-09-24T18:15:14+00:00","read_at_is":"when the build read Syntology's graph, not when any sample ran","claim":"Per-sample execution status on synthesized fixtures; not a correctness claim about the paper. Samples come from repositories linked to the paper, official or community; repo_kind says which.","repos":[{"provenance":"deterministic:regex_extraction","url":"https://github.com/heyblackC/DFMIR","reach":null}],"summary":{"ran":20,"ran_fixture":3,"ran_draft_wrong":4,"ran_honours":1,"ran_violates":1,"unverified":7},"by_repo_kind":{"official":{"samples":34,"ran":27,"repositories":1}},"repo_kind_vocabulary":{"official":"The archive marks this repository official for the paper","named_in_paper":"The archive records that the paper mentions this repository; it is not marked official","listed":"In the archive's code links for this paper, not marked official and not recorded as mentioned in the paper","found_in_text":"Syntology found this repository in the paper's own text; whether it is the authors' implementation is not asserted","community":"Not in the archive's code links for this paper; a community repository Syntology harvested"},"n_pointer_only_for_licence":36,"samples":[{"code_sha256_prefix":"1db3e55c3b8b11aa","entry":"Blur","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"1db3e55c3b8b11aa"}},{"code_sha256_prefix":"7b14ce86e7859f93","entry":"ContentEncoder","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"7b14ce86e7859f93"}},{"code_sha256_prefix":"28eb965164e16100","entry":"Conv2dBlock","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"28eb965164e16100"}},{"code_sha256_prefix":"d163291e61c44389","entry":"ConvLayer","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"d163291e61c44389"}},{"code_sha256_prefix":"747bcf08bb0add92","entry":"Decoder","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"747bcf08bb0add92"}},{"code_sha256_prefix":"33812f54928e9382","entry":"Decoder_all","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"33812f54928e9382"}},{"code_sha256_prefix":"7f3677d806b3c27d","entry":"Downsample","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"7f3677d806b3c27d"}},{"code_sha256_prefix":"806eb7ba2ad7e694","entry":"EqualConv2d","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"806eb7ba2ad7e694"}},{"code_sha256_prefix":"c76376ad33ce633d","entry":"EqualLinear","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"c76376ad33ce633d"}},{"code_sha256_prefix":"12b67cecb13e3209","entry":"FusedLeakyReLU","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"12b67cecb13e3209"}},{"code_sha256_prefix":"0da3208c8f382862","entry":"LayerNorm","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"0da3208c8f382862"}},{"code_sha256_prefix":"20786c011783fa9c","entry":"ModulatedConv2d","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"20786c011783fa9c"}},{"code_sha256_prefix":"65a8f5e5f6dedf16","entry":"ResBlock","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"65a8f5e5f6dedf16"}},{"code_sha256_prefix":"8af7af23249bd476","entry":"ResBlocks","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"8af7af23249bd476"}},{"code_sha256_prefix":"c8465b2e024c8c4c","entry":"ResnetGenerator","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"c8465b2e024c8c4c"}},{"code_sha256_prefix":"bb3374f370134992","entry":"ScaledLeakyReLU","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"bb3374f370134992"}},{"code_sha256_prefix":"6622a698d50ddaf9","entry":"UnetGenerator","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"6622a698d50ddaf9"}},{"code_sha256_prefix":"f1612e4623636819","entry":"UnetSkipConnectionBlock","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"f1612e4623636819"}},{"code_sha256_prefix":"6576414e1c6d6538","entry":"Upsample","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"6576414e1c6d6538"}},{"code_sha256_prefix":"e2239e9469e3eab7","entry":"Upsample2","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"e2239e9469e3eab7"}},{"code_sha256_prefix":"f844b58083ed2820","entry":"cat_feature","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran_fixture","verification_level":1,"contract_check":"RAISES","metamorphic_tier":null,"behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"f844b58083ed2820"}},{"code_sha256_prefix":"52e473db1efd9a5a","entry":"fused_leaky_relu","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran_draft_wrong","verification_level":1,"contract_check":"MISDECLARED","metamorphic_tier":null,"behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"52e473db1efd9a5a"}},{"code_sha256_prefix":"acc24402a2d089fa","entry":"get_filter","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran_honours","verification_level":1,"contract_check":"HONOURS","metamorphic_tier":null,"behaviour_fingerprint":true,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"acc24402a2d089fa"}},{"code_sha256_prefix":"b27dffc0609fbec0","entry":"get_norm_layer","repo":null,"repo_kind":null,"path":null,"file_url":null,"link_basis":"identical_code_first_harvested_elsewhere","language":"python","status":"ran_draft_wrong","verification_level":1,"contract_check":"OUTPUT_MISDECLARED","metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":null,"inline_ok":false,"mcp_get_code":{"code_sha256":"b27dffc0609fbec0"}},{"code_sha256_prefix":"50aa4a59fe718c61","entry":"get_pad_layer","repo":null,"repo_kind":null,"path":null,"file_url":null,"link_basis":"identical_code_first_harvested_elsewhere","language":"python","status":"ran_draft_wrong","verification_level":1,"contract_check":"OUTPUT_MISDECLARED","metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":null,"inline_ok":false,"mcp_get_code":{"code_sha256":"50aa4a59fe718c61"}},{"code_sha256_prefix":"01d1ccc6bbadcbdc","entry":"init_net","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran_draft_wrong","verification_level":1,"contract_check":"OUTPUT_MISDECLARED","metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"01d1ccc6bbadcbdc"}},{"code_sha256_prefix":"e63386bfb3576b21","entry":"make_kernel","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran_violates","verification_level":1,"contract_check":"VIOLATES","metamorphic_tier":"well_formed","behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"e63386bfb3576b21"}},{"code_sha256_prefix":"8834a164daa9b95b","entry":"upfirdn2d","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran_fixture","verification_level":1,"contract_check":"RAISES","metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"8834a164daa9b95b"}},{"code_sha256_prefix":"635cc3f168503039","entry":"upfirdn2d_native","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"ran_fixture","verification_level":1,"contract_check":"RAISES","metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"635cc3f168503039"}},{"code_sha256_prefix":"5cdd3a7100cc69ce","entry":"G_Resnet","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"5cdd3a7100cc69ce"}},{"code_sha256_prefix":"41e13bca6e8ab257","entry":"StyleGAN2Decoder","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"41e13bca6e8ab257"}},{"code_sha256_prefix":"bf4e03c1cd041ae4","entry":"StyleGAN2Encoder","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"bf4e03c1cd041ae4"}},{"code_sha256_prefix":"e0c2357fd338ead7","entry":"StyleGAN2Generator","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"e0c2357fd338ead7"}},{"code_sha256_prefix":"e4a2e3e30d428db8","entry":"StyledConv","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"e4a2e3e30d428db8"}},{"code_sha256_prefix":"18d7842e0778878b","entry":"define_G","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"18d7842e0778878b"}},{"code_sha256_prefix":"6346533200f005a9","entry":"init_weights","repo":"heyblackC/DFMIR","repo_kind":"official","path":"models/networks.py","file_url":"https://github.com/heyblackC/DFMIR/blob/HEAD/models/networks.py","link_basis":"first_harvest_node","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"NONE","inline_ok":false,"mcp_get_code":{"code_sha256":"6346533200f005a9"}}]},"arxiv_metadata":null,"syntology_extracted_results":null}