{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/unsupervised-discovery-of-toxoplasma-gondii","title":"Unsupervised Discovery of Toxoplasma gondii Motility Phenotypes","arxiv_id":"1801.02591","date":"2018-01-08","proceeding":null,"authors":["Mojtaba S. Fazli","Stephen A. Vella","Silvia N. J. Moreno","Shannon Quinn"],"abstract":"Toxoplasma gondii is a parasitic protozoan that causes dis- seminated\ntoxoplasmosis, a disease that afflicts roughly a third of the worlds\npopulation. Its virulence is predicated on its motility and ability to enter\nand exit nucleated cells; therefore, studies elucidating its mechanism of\nmotility and in particular, its motility patterns in the context of its lytic\ncycle, are critical to the eventual development of therapeutic strate- gies.\nHere, we present an end-to-end computational pipeline for identifying T. gondii\nmotility phenotypes in a completely unsupervised, data-driven way. We track the\nparasites before and after addition of extracellular Ca2+ to study its effects\non the parasite motility patterns and use this information to parameterize the\nmotion and group it according to similarity of spatiotemporal dynamics.","url_abs":"http://arxiv.org/abs/1801.02591v2","url_pdf":"http://arxiv.org/pdf/1801.02591v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"unsupervised-discovery-of-toxoplasma-gondii","repo_url":"https://github.com/quinngroup/toxoplasma-isbi2018","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}