{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/teravr-empowers-precise-reconstruction-of","title":"TeraVR empowers precise reconstruction of complete 3-D neuronal morphology in the whole brain","arxiv_id":null,"date":"2019-08-02","proceeding":"Nature Communicationsvolume 10, Article number: 3474 (2019) 2019 8","authors":["Yimin Wang","Qi Li","Li-Juan Liu","Zhi Zhou","Zongcai Ruan","Lingsheng Kong","Yaoyao Li","Yun Wang","Ning Zhong","Renjie Chai","Xiangfeng Luo","Yike Guo","Michael Hawrylycz","Qingming Luo","Zhongze Gu","Wei Xie","Hongkui Zeng","Hanchuan Peng"],"abstract":"Neuron morphology is recognized as a key determinant of cell type, yet the quantitative profiling of a mammalian neuron’s complete three-dimensional (3-D) morphology remains arduous when the neuron has complex arborization and long projection. Whole-brain reconstruction of neuron morphology is even more challenging as it involves processing tens of teravoxels of imaging data. Validating such reconstructions is extremely laborious. We develop TeraVR, an open-source virtual reality annotation system, to address these challenges. TeraVR integrates immersive and collaborative 3-D visualization, interaction, and hierarchical streaming of teravoxel-scale images. Using TeraVR, we have produced precise 3-D full morphology of long-projecting neurons in whole mouse brains and developed a collaborative workflow for highly accurate neuronal reconstruction.","url_abs":"https://doi.org/10.1038/s41467-019-11443-y","url_pdf":"https://www.nature.com/articles/s41467-019-11443-y.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"teravr-empowers-precise-reconstruction-of","repo_url":"https://github.com/Vaa3D/release","is_official":0,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[{"task_slug":"electron-microscopy-image-segmentation","task_name":"Electron Microscopy Image Segmentation"},{"task_slug":"image-reconstruction","task_name":"Image Reconstruction"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}