{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/sprint-ultrafast-protein-protein-interaction","title":"SPRINT: Ultrafast protein-protein interaction prediction of the entire human interactome","arxiv_id":"1705.06848","date":"2017-05-19","proceeding":null,"authors":[],"abstract":"Proteins perform their functions usually by interacting with other proteins.\nPredicting which proteins interact is a fundamental problem. Experimental\nmethods are slow, expensive, and have a high rate of error. Many computational\nmethods have been proposed among which sequence-based ones are very promising.\nHowever, so far no such method is able to predict effectively the entire human\ninteractome: they require too much time or memory. We present SPRINT (Scoring\nPRotein INTeractions), a new sequence-based algorithm and tool for predicting\nprotein-protein interactions. We comprehensively compare SPRINT with\nstate-of-the-art programs on seven most reliable human PPI datasets and show\nthat it is more accurate while running orders of magnitude faster and using\nvery little memory. SPRINT is the only program that can predict the entire\nhuman interactome. Our goal is to transform the very challenging problem of\npredicting the entire human interactome into a routine task. The source code of\nSPRINT is freely available from github.com/lucian-ilie/SPRINT/ and the datasets\nand predicted PPIs from www.csd.uwo.ca/faculty/ilie/SPRINT/.","url_abs":"http://arxiv.org/abs/1705.06848v1","url_pdf":"http://arxiv.org/pdf/1705.06848v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"sprint-ultrafast-protein-protein-interaction","repo_url":"https://github.com/lucian-ilie/SPRINT","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}