{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/semidefinite-relaxations-in-optimal","title":"Semidefinite relaxations in optimal experiment design with application to substrate injection for hyperpolarized MRI","arxiv_id":"1510.00455","date":"2015-10-02","proceeding":null,"authors":["John Maidens","Murat Arcak"],"abstract":"We consider the problem of optimal input design for estimating uncertain parameters in a discrete-time linear state space model, subject to simultaneous amplitude and l1/l2-norm constraints on the admissible inputs. We formulate this problem as the maximization of a (non-concave) quadratic function over the space of inputs, and use semidefinite relaxation techniques to efficiently find the global solution or to provide an upper bound. This investigation is motivated by a problem in medical imaging, specifically designing a substrate injection profile for in vivo metabolic parameter mapping using magnetic resonance imaging (MRI) with hyperpolarized carbon-13 pyruvate. In the l2-norm-constrained case, we show that the relaxation is tight, allowing us to efficiently compute a globally optimal injection profile. In the l1-norm-constrained case the relaxation is no longer tight, but can be used to prove that the boxcar injection currently used in practice achieves at least 98.7% of the global optimum.","url_abs":"http://arxiv.org/abs/1510.00455v2","url_pdf":"http://arxiv.org/pdf/1510.00455v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"links_only","authors_date_abstract":"arXiv metadata, CC0 1.0 (https://info.arxiv.org/help/license), from the Kaggle arXiv metadata snapshot of 2026-09-12"},"code_links":[{"paper_slug":"semidefinite-relaxations-in-optimal","repo_url":"https://github.com/maidens/ACC-2016","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}