{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/segx-improving-interpretability-of-clinical","title":"SegX: Improving Interpretability of Clinical Image Diagnosis with Segmentation-based Enhancement","arxiv_id":"2502.10296","date":"2025-02-14","proceeding":null,"authors":["Yuhao Zhang","Mingcheng Zhu","Zhiyao Luo"],"abstract":"Deep learning-based medical image analysis faces a significant barrier due to the lack of interpretability. Conventional explainable AI (XAI) techniques, such as Grad-CAM and SHAP, often highlight regions outside clinical interests. To address this issue, we propose Segmentation-based Explanation (SegX), a plug-and-play approach that enhances interpretability by aligning the model's explanation map with clinically relevant areas leveraging the power of segmentation models. Furthermore, we introduce Segmentation-based Uncertainty Assessment (SegU), a method to quantify the uncertainty of the prediction model by measuring the 'distance' between interpretation maps and clinically significant regions. Our experiments on dermoscopic and chest X-ray datasets show that SegX improves interpretability consistently across mortalities, and the certainty score provided by SegU reliably reflects the correctness of the model's predictions. Our approach offers a model-agnostic enhancement to medical image diagnosis towards reliable and interpretable AI in clinical decision-making.","url_abs":"https://arxiv.org/abs/2502.10296v1","url_pdf":"https://arxiv.org/pdf/2502.10296v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"segx-improving-interpretability-of-clinical","repo_url":"https://github.com/JasonZuu/SegX","is_official":1,"mentioned_in_paper":0,"mentioned_in_github":1,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"decision-making","task_name":"Decision Making"},{"task_slug":"medical-image-analysis","task_name":"Medical Image Analysis"},{"task_slug":"segmentation","task_name":"Segmentation"}],"methods":[{"method_slug":"shap","method_name":"SHAP"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}