{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/robust-machine-learning-segmentation-for","title":"Robust machine learning segmentation for large-scale analysis of heterogeneous clinical brain MRI datasets","arxiv_id":"2209.02032","date":"2022-09-05","proceeding":null,"authors":["Benjamin Billot","Colin Magdamo","You Cheng","Steven E. Arnold","Sudeshna Das","Juan. E. Iglesias"],"abstract":"Every year, millions of brain MRI scans are acquired in hospitals, which is a figure considerably larger than the size of any research dataset. Therefore, the ability to analyse such scans could transform neuroimaging research. Yet, their potential remains untapped, since no automated algorithm is robust enough to cope with the high variability in clinical acquisitions (MR contrasts, resolutions, orientations, artefacts, subject populations). Here we present SynthSeg+, an AI segmentation suite that enables, for the first time, robust analysis of heterogeneous clinical datasets. In addition to whole-brain segmentation, SynthSeg+ also performs cortical parcellation, intracranial volume estimation, and automated detection of faulty segmentations (mainly caused by scans of very low quality). We demonstrate SynthSeg+ in seven experiments, including an ageing study on 14,000 scans, where it accurately replicates atrophy patterns observed on data of much higher quality. SynthSeg+ is publicly released as a ready-to-use tool to unlock the potential of quantitative morphometry.","url_abs":"https://arxiv.org/abs/2209.02032v2","url_pdf":"https://arxiv.org/pdf/2209.02032v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"robust-machine-learning-segmentation-for","repo_url":"https://github.com/BBillot/SynthSeg","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"tf","reach":{"status":"ok","spdx":"Apache-2.0"}}],"tasks":[{"task_slug":"brain-segmentation","task_name":"Brain Segmentation"},{"task_slug":"segmentation","task_name":"Segmentation"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":"https://app.syntology.ai/?focus=2209.02032","mcp":{"get_harvested_code_for_paper":{"arxiv_id":"2209.02032"}},"developers":"https://syntology.ai/developers","read_at":"2026-09-24T18:15:14+00:00","read_at_is":"when the build read Syntology's graph, not when any sample ran","claim":"Per-sample execution status on synthesized fixtures; not a correctness claim about the paper. Samples come from repositories linked to the paper, official or community; repo_kind says which.","repos":[{"provenance":"external:paperswithcode_snapshot_2025-07-28","url":"https://github.com/BBillot/SynthSeg","reach":{"status":"ok","spdx":"Apache-2.0"}}],"summary":{"unverified":2},"by_repo_kind":{"official":{"samples":2,"ran":0,"repositories":1}},"repo_kind_vocabulary":{"official":"The archive marks this repository official for the paper","named_in_paper":"The archive records that the paper mentions this repository; it is not marked official","listed":"In the archive's code links for this paper, not marked official and not recorded as mentioned in the paper","found_in_text":"Syntology found this repository in the paper's own text; whether it is the authors' implementation is not asserted","community":"Not in the archive's code links for this paper; a community repository Syntology harvested"},"n_pointer_only_for_licence":0,"samples":[{"code_sha256_prefix":"1e89532c92f49ac1","entry":"dice","repo":"BBillot/SynthSeg","repo_kind":"official","path":"SynthSeg/evaluate.py","file_url":"https://github.com/BBillot/SynthSeg/blob/HEAD/SynthSeg/evaluate.py","link_basis":"harvester_set","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"Apache-2.0","inline_ok":true,"mcp_get_code":{"code_sha256":"1e89532c92f49ac1"}},{"code_sha256_prefix":"e7f1df563aa4005f","entry":"fast_dice","repo":"BBillot/SynthSeg","repo_kind":"official","path":"SynthSeg/evaluate.py","file_url":"https://github.com/BBillot/SynthSeg/blob/HEAD/SynthSeg/evaluate.py","link_basis":"harvester_set","language":"python","status":"unverified","verification_level":0,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":false,"licence":"Apache-2.0","inline_ok":true,"mcp_get_code":{"code_sha256":"e7f1df563aa4005f"}}]},"arxiv_metadata":null,"syntology_extracted_results":null}