{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/replication-of-sars-cov-2-mutation-analysis","title":"Replication of SARS-CoV-2 mutation analysis suggests differences in per-protein mutation characteristics","arxiv_id":"2112.07770","date":"2021-12-14","proceeding":null,"authors":["William Svoboda","Brendan McManamon","Sara Schwartz"],"abstract":"The increasing spread of COVID-19, caused by the virus SARS-CoV-2, raises concerns about the extent to which mutations have occurred across the viral genome. We present a partial replication of an earlier 2021 study by Wang, R. et al. that determined the presence of four substrains and eleven top mutations in the United States. We analyze a portion of the authors' data set in order to recreate Figure S1 from the paper, recapitulating the same features observed in the original figure. We further generate a summary of mutation characteristics for each of the 26 named proteins and confirm the significance of the spike protein at roughly 24% of all recorded mutations. Our analysis suggests that additional factors may affect per-protein mutation rate besides protein length.","url_abs":"https://arxiv.org/abs/2112.07770v2","url_pdf":"https://arxiv.org/pdf/2112.07770v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"replication-of-sars-cov-2-mutation-analysis","repo_url":"https://github.com/thisstillwill/qcb455-fall-2021","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}