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Here, we propose a new Bayesian convolutional neural network (BNN)-based framework that overcomes this issue by quantifying the uncertainty of DL predictions. Foremost, we show that BNN-predicted uncertainty maps provide surrogate estimates of the true error from the network model and measurement itself. The uncertainty maps characterize imperfections often unknown in real-world applications, such as noise, model error, incomplete training data, and out-of-distribution testing data. Quantifying this uncertainty provides a per-pixel estimate of the confidence level of the DL prediction as well as the quality of the model and dataset. We demonstrate this framework in the application of large space-bandwidth product phase imaging using a physics-guided coded illumination scheme. From only five multiplexed illumination measurements, our BNN predicts gigapixel phase images in both static and dynamic biological samples with quantitative credibility assessment. Furthermore, we show that low-certainty regions can identify spatially and temporally rare biological phenomena. We believe our uncertainty learning framework is widely applicable to many DL-based biomedical imaging techniques for assessing the reliability of DL predictions.","url_abs":"https://arxiv.org/abs/1901.02038v4","url_pdf":"https://arxiv.org/pdf/1901.02038v4.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"reliable-deep-learning-based-phase-imaging","repo_url":"https://github.com/bu-cisl/illumination-coding-meets-uncertainty-learning","is_official":1,"mentioned_in_paper":0,"mentioned_in_github":0,"framework":"tf","reach":{"status":"ok","spdx":"BSD-3-Clause"}}],"tasks":[{"task_slug":"deep-learning","task_name":"Deep Learning"},{"task_slug":"uncertainty-quantification","task_name":"Uncertainty Quantification"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":"https://app.syntology.ai/?focus=1901.02038","mcp":{"get_harvested_code_for_paper":{"arxiv_id":"1901.02038"}},"developers":"https://syntology.ai/developers","read_at":"2026-09-24T18:15:14+00:00","read_at_is":"when the build read Syntology's graph, not when any sample ran","claim":"Per-sample execution status on synthesized fixtures; not a correctness claim about the paper. 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