{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/physics-regularized-multi-modal-image","title":"Physics-Regularized Multi-Modal Image Assimilation for Brain Tumor Localization","arxiv_id":"2409.20409","date":"2024-09-30","proceeding":null,"authors":["Michal Balcerak","Tamaz Amiranashvili","Andreas Wagner","Jonas Weidner","Petr Karnakov","Johannes C. Paetzold","Ivan Ezhov","Petros Koumoutsakos","Benedikt Wiestler","Bjoern Menze"],"abstract":"Physical models in the form of partial differential equations serve as important priors for many under-constrained problems. One such application is tumor treatment planning, which relies on accurately estimating the spatial distribution of tumor cells within a patient's anatomy. While medical imaging can detect the bulk of a tumor, it cannot capture the full extent of its spread, as low-concentration tumor cells often remain undetectable, particularly in glioblastoma, the most common primary brain tumor. Machine learning approaches struggle to estimate the complete tumor cell distribution due to a lack of appropriate training data. Consequently, most existing methods rely on physics-based simulations to generate anatomically and physiologically plausible estimations. However, these approaches face challenges with complex and unknown initial conditions and are constrained by overly rigid physical models. In this work, we introduce a novel method that integrates data-driven and physics-based cost functions, akin to Physics-Informed Neural Networks (PINNs). However, our approach parametrizes the solution directly on a dynamic discrete mesh, allowing for the effective modeling of complex biomechanical behaviors. Specifically, we propose a unique discretization scheme that quantifies how well the learned spatiotemporal distributions of tumor and brain tissues adhere to their respective growth and elasticity equations. This quantification acts as a regularization term, offering greater flexibility and improved integration of patient data compared to existing models. We demonstrate enhanced coverage of tumor recurrence areas using real-world data from a patient cohort, highlighting the potential of our method to improve model-driven treatment planning for glioblastoma in clinical practice.","url_abs":"https://arxiv.org/abs/2409.20409v3","url_pdf":"https://arxiv.org/pdf/2409.20409v3.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"physics-regularized-multi-modal-image","repo_url":"https://github.com/m1balcerak/PhysRegTumor","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":{"status":"ok","spdx":"MIT"}}],"tasks":[{"task_slug":"anatomy","task_name":"Anatomy"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":"https://app.syntology.ai/?focus=2409.20409","mcp":{"get_harvested_code_for_paper":{"arxiv_id":"2409.20409"}},"developers":"https://syntology.ai/developers","read_at":"2026-09-24T18:15:14+00:00","read_at_is":"when the build read Syntology's graph, not when any sample ran","claim":"Per-sample execution status on synthesized fixtures; not a correctness claim about the paper. Samples come from repositories linked to the paper, official or community; repo_kind says which.","repos":[{"provenance":"external:paperswithcode_snapshot_2025-07-28","url":"https://github.com/m1balcerak/PhysRegTumor","reach":{"status":"ok","spdx":"MIT"}}],"summary":{"ran":1},"by_repo_kind":{"official":{"samples":1,"ran":1,"repositories":1}},"repo_kind_vocabulary":{"official":"The archive marks this repository official for the paper","named_in_paper":"The archive records that the paper mentions this repository; it is not marked official","listed":"In the archive's code links for this paper, not marked official and not recorded as mentioned in the paper","found_in_text":"Syntology found this repository in the paper's own text; whether it is the authors' implementation is not asserted","community":"Not in the archive's code links for this paper; a community repository Syntology harvested"},"n_pointer_only_for_licence":0,"samples":[{"code_sha256_prefix":"aba6817147a9dc82","entry":"correct_outside_skull_mask","repo":"m1balcerak/PhysRegTumor","repo_kind":"official","path":"data_processing.py","file_url":"https://github.com/m1balcerak/PhysRegTumor/blob/HEAD/data_processing.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":null,"behaviour_fingerprint":true,"licence":"MIT","inline_ok":true,"mcp_get_code":{"code_sha256":"aba6817147a9dc82"}}]},"arxiv_metadata":null,"syntology_extracted_results":null}