{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/patient-specific-models-of-treatment-effects","title":"Patient-Specific Models of Treatment Effects Explain Heterogeneity in Tuberculosis","arxiv_id":"2411.10645","date":"2024-11-16","proceeding":null,"authors":["Ethan Wu","Caleb Ellington","Ben Lengerich","Eric P. Xing"],"abstract":"Tuberculosis (TB) is a major global health challenge, and is compounded by co-morbidities such as HIV, diabetes, and anemia, which complicate treatment outcomes and contribute to heterogeneous patient responses. Traditional models of TB often overlook this heterogeneity by focusing on broad, pre-defined patient groups, thereby missing the nuanced effects of individual patient contexts. We propose moving beyond coarse subgroup analyses by using contextualized modeling, a multi-task learning approach that encodes patient context into personalized models of treatment effects, revealing patient-specific treatment benefits. Applied to the TB Portals dataset with multi-modal measurements for over 3,000 TB patients, our model reveals structured interactions between co-morbidities, treatments, and patient outcomes, identifying anemia, age of onset, and HIV as influential for treatment efficacy. By enhancing predictive accuracy in heterogeneous populations and providing patient-specific insights, contextualized models promise to enable new approaches to personalized treatment.","url_abs":"https://arxiv.org/abs/2411.10645v1","url_pdf":"https://arxiv.org/pdf/2411.10645v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"patient-specific-models-of-treatment-effects","repo_url":"https://github.com/ethanwu2011/ContextualizedTB","is_official":1,"mentioned_in_paper":0,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[{"task_slug":"multi-task-learning","task_name":"Multi-Task Learning"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}