{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/modelling-cross-reactivity-and-memory-in-the","title":"Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host","arxiv_id":"1606.00495","date":"2016-11-22","proceeding":null,"authors":[],"abstract":"The cellular adaptive immune response plays a key role in resolving influenza\ninfection. Experiments where individuals are successively infected with\ndifferent strains within a short timeframe provide insight into the underlying\nviral dynamics and the role of a cross-reactive immune response in resolving an\nacute infection. We construct a mathematical model of within-host influenza\nviral dynamics including three possible factors which determine the strength of\nthe cross-reactive cellular adaptive immune response: the initial naive T cell\nnumber, the avidity of the interaction between T cells and the epitopes\npresented by infected cells, and the epitope abundance per infected cell. Our\nmodel explains the experimentally observed shortening of a second infection\nwhen cross-reactivity is present, and shows that memory in the cellular\nadaptive immune response is necessary to protect against a second infection.","url_abs":"http://arxiv.org/abs/1606.00495v2","url_pdf":"http://arxiv.org/pdf/1606.00495v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"modelling-cross-reactivity-and-memory-in-the","repo_url":"https://bitbucket.org/ada_yan/cross-reactivity","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}