{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/mixing-histopathology-prototypes-into-robust","title":"Mixing Histopathology Prototypes into Robust Slide-Level Representations for Cancer Subtyping","arxiv_id":"2310.12769","date":"2023-10-19","proceeding":null,"authors":["Joshua Butke","Noriaki Hashimoto","Ichiro Takeuchi","Hiroaki Miyoshi","Koichi Ohshima","Jun Sakuma"],"abstract":"Whole-slide image analysis via the means of computational pathology often relies on processing tessellated gigapixel images with only slide-level labels available. Applying multiple instance learning-based methods or transformer models is computationally expensive as, for each image, all instances have to be processed simultaneously. The MLP-Mixer is an under-explored alternative model to common vision transformers, especially for large-scale datasets. Due to the lack of a self-attention mechanism, they have linear computational complexity to the number of input patches but achieve comparable performance on natural image datasets. We propose a combination of feature embedding and clustering to preprocess the full whole-slide image into a reduced prototype representation which can then serve as input to a suitable MLP-Mixer architecture. Our experiments on two public benchmarks and one inhouse malignant lymphoma dataset show comparable performance to current state-of-the-art methods, while achieving lower training costs in terms of computational time and memory load. Code is publicly available at https://github.com/butkej/ProtoMixer.","url_abs":"https://arxiv.org/abs/2310.12769v1","url_pdf":"https://arxiv.org/pdf/2310.12769v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"mixing-histopathology-prototypes-into-robust","repo_url":"https://github.com/butkej/protomixer","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"multiple-instance-learning","task_name":"Multiple Instance Learning"}],"methods":[{"method_slug":"average-pooling","method_name":"Average Pooling"},{"method_slug":"dense-connections","method_name":"Dense Connections"},{"method_slug":"dropout","method_name":"Dropout"},{"method_slug":"global-average-pooling","method_name":"Global Average Pooling"},{"method_slug":"layer-normalization","method_name":"Layer Normalization"},{"method_slug":"mlp-mixer","method_name":"MLP-Mixer"},{"method_slug":"residual-connection","method_name":"Residual Connection"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}