{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/mfm-da-instance-aware-adaptor-and","title":"MFM-DA: Instance-Aware Adaptor and Hierarchical Alignment for Efficient Domain Adaptation in Medical Foundation Models","arxiv_id":"2503.00802","date":"2025-03-02","proceeding":null,"authors":["Jia-Xuan Jiang","Wenhui Lei","Yifeng Wu","Hongtao Wu","Furong Li","Yining Xie","Xiaofan Zhang","Zhong Wang"],"abstract":"Medical Foundation Models (MFMs), trained on large-scale datasets, have demonstrated superior performance across various tasks. However, these models still struggle with domain gaps in practical applications. Specifically, even after fine-tuning on source-domain data, task-adapted foundation models often perform poorly in the target domain. To address this challenge, we propose a few-shot unsupervised domain adaptation (UDA) framework for MFMs, named MFM-DA, which only leverages a limited number of unlabeled target-domain images. Our approach begins by training a Denoising Diffusion Probabilistic Model (DDPM), which is then adapted to the target domain using a proposed dynamic instance-aware adaptor and a distribution direction loss, enabling the DDPM to translate source-domain images into the target domain style. The adapted images are subsequently processed through the MFM, where we introduce a designed channel-spatial alignment Low-Rank Adaptation (LoRA) to ensure effective feature alignment. Extensive experiments on optic cup and disc segmentation tasks demonstrate that MFM-DA outperforms state-of-the-art methods. Our work provides a practical solution to the domain gap issue in real-world MFM deployment. Code will be available at here.","url_abs":"https://arxiv.org/abs/2503.00802v1","url_pdf":"https://arxiv.org/pdf/2503.00802v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"mfm-da-instance-aware-adaptor-and","repo_url":"https://github.com/HopkinsKwong/MFM-DA","is_official":1,"mentioned_in_paper":0,"mentioned_in_github":1,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"denoising","task_name":"Denoising"},{"task_slug":"domain-adaptation","task_name":"Domain Adaptation"},{"task_slug":"unsupervised-domain-adaptation","task_name":"Unsupervised Domain Adaptation"}],"methods":[{"method_slug":"diffusion","method_name":"Diffusion"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}