{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/mensadb-a-thorough-structural-analysis-of","title":"MENSADB: A Thorough Structural Analysis of Membrane Protein Dimers","arxiv_id":"1902.02321","date":"2019-02-06","proceeding":null,"authors":["Pedro Matos-Filipe","António J. Preto","Panagiotis I. Koukos","Joana Mourão","Alexandre M. J. J. Bonvin","Irina S. Moreira"],"abstract":"Membrane Proteins (MPs) account for around 15-39% of the human proteome and assume a critical role in a vast set of cellular and physiological mechanisms, including molecular transport, nutrient uptake, toxin and waste product clearance, respiration, and signaling. While roughly 60% of all FDA-approved drugs target MPs, there is a shortage of structural and biochemical data on them mainly hindered by their localization in the lipid bilayer. We present here MEmbrane protein dimer Novel Structure Analyser database (MENSAdb), a real time web-application exposing a broad array of fundamental features about MPs surface and their interfacial regions. In particular, we present conservation, four distinctive Accessible Solvent Area (ASA) descriptors, average and environment-specific B-factors, intermolecular contacts at 2.5 and 4.0 angstroms distance cutoffs, salt-bridges, hydrogen-bonds, hydrophobic, pi-pi interactions, t-stacking and cation-pi interactions. Additionally, users can closely inspect differences in values between three distinctive residues classes: i) non-surface, ii) surface and non-interfacial and iii) interfacial. The database is freely available at www.moreiralab.com/resources/mensadb.","url_abs":"https://arxiv.org/abs/1902.02321v1","url_pdf":"https://arxiv.org/pdf/1902.02321v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"mensadb-a-thorough-structural-analysis-of","repo_url":"https://github.com/MoreiraLAB/mensadb-open","is_official":0,"mentioned_in_paper":0,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}