{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/measurement-error-and-precision-medicine","title":"Measurement error and precision medicine: error-prone tailoring covariates in dynamic treatment regimes","arxiv_id":"1907.11659","date":"2019-07-26","proceeding":null,"authors":["Dylan Spicker","Michael Wallace"],"abstract":"Precision medicine incorporates patient-level covariates to tailor treatment decisions, seeking to improve outcomes. In longitudinal studies with time-varying covariates and sequential treatment decisions, precision medicine can be formalized with dynamic treatment regimes (DTRs): sequences of covariate-dependent treatment rules. To date, the precision medicine literature has not addressed a ubiquitous concern in health research - measurement error - where observed data deviate from the truth. We discuss the consequences of ignoring measurement error in the context of DTRs, focusing on challenges unique to precision medicine. We show - through simulation and theoretical results - that relatively simple measurement error correction techniques can lead to substantial improvements over uncorrected analyses, and apply these findings to the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study.","url_abs":"http://arxiv.org/abs/1907.11659v3","url_pdf":"http://arxiv.org/pdf/1907.11659v3.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"links_only","authors_date_abstract":"arXiv metadata, CC0 1.0 (https://info.arxiv.org/help/license), from the Kaggle arXiv metadata snapshot of 2026-09-12"},"code_links":[{"paper_slug":"measurement-error-and-precision-medicine","repo_url":"https://github.com/DylanSpicker/measurement-error-DTRs","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}