{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/lung-ddpm-semantic-layout-guided-diffusion","title":"Lung-DDPM: Semantic Layout-guided Diffusion Models for Thoracic CT Image Synthesis","arxiv_id":"2502.15204","date":"2025-02-21","proceeding":null,"authors":["Yifan Jiang","Yannick Lemaréchal","Josée Bafaro","Jessica Abi-Rjeile","Philippe Joubert","Philippe Després","Venkata Manem"],"abstract":"With the rapid development of artificial intelligence (AI), AI-assisted medical imaging analysis demonstrates remarkable performance in early lung cancer screening. However, the costly annotation process and privacy concerns limit the construction of large-scale medical datasets, hampering the further application of AI in healthcare. To address the data scarcity in lung cancer screening, we propose Lung-DDPM, a thoracic CT image synthesis approach that effectively generates high-fidelity 3D synthetic CT images, which prove helpful in downstream lung nodule segmentation tasks. Our method is based on semantic layout-guided denoising diffusion probabilistic models (DDPM), enabling anatomically reasonable, seamless, and consistent sample generation even from incomplete semantic layouts. Our results suggest that the proposed method outperforms other state-of-the-art (SOTA) generative models in image quality evaluation and downstream lung nodule segmentation tasks. Specifically, Lung-DDPM achieved superior performance on our large validation cohort, with a Fr\\'echet inception distance (FID) of 0.0047, maximum mean discrepancy (MMD) of 0.0070, and mean squared error (MSE) of 0.0024. These results were 7.4$\\times$, 3.1$\\times$, and 29.5$\\times$ better than the second-best competitors, respectively. Furthermore, the lung nodule segmentation model, trained on a dataset combining real and Lung-DDPM-generated synthetic samples, attained a dice coefficient (Dice) of 0.3914 and sensitivity of 0.4393. This represents 8.8\\% and 18.6\\% improvements in DICE and sensitivity compared to the model trained solely on real samples. The experimental results highlight Lung-DDPM's potential for a broader range of medical imaging applications, such as general tumor segmentation, cancer survival estimation, and risk prediction.","url_abs":"https://arxiv.org/abs/2502.15204v1","url_pdf":"https://arxiv.org/pdf/2502.15204v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"lung-ddpm-semantic-layout-guided-diffusion","repo_url":"https://github.com/manem-lab/lung-ddpm","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":1,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"denoising","task_name":"Denoising"},{"task_slug":"image-generation","task_name":"Image Generation"},{"task_slug":"lung-nodule-segmentation","task_name":"Lung Nodule Segmentation"},{"task_slug":"segmentation","task_name":"Segmentation"},{"task_slug":"sensitivity","task_name":"Sensitivity"},{"task_slug":"tumor-segmentation","task_name":"Tumor Segmentation"}],"methods":[{"method_slug":"diffusion","method_name":"Diffusion"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}