{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/longitudinal-latent-overall-toxicity-lotox","title":"Longitudinal Latent Overall Toxicity (LOTox) profiles in osteosarcoma: a new taxonomy based on latent Markov models","arxiv_id":"2107.12863","date":"2021-07-27","proceeding":null,"authors":["Marta Spreafico","Francesca Ieva","Marta Fiocco"],"abstract":"Due to the presence of multiple types of adverse events with different levels of severity, the analysis of longitudinal toxicity data is a difficult task in cancer studies. In this work, a novel approach based on latent Markov models and compositional data techniques is proposed. The latent status of interest is the Latent Overall Toxicity (LOTox) condition of each patient. The main objectives consist in identifying different latent states of overall toxicity burden and investigating the evolution of individual toxicity risk during cancer treatment. This methodology is applied to osteosarcoma treatment data to provide novel techniques that may support medical decisions in childhood cancer therapy.","url_abs":"https://arxiv.org/abs/2107.12863v3","url_pdf":"https://arxiv.org/pdf/2107.12863v3.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"links_only","authors_date_abstract":"arXiv metadata, CC0 1.0 (https://info.arxiv.org/help/license), from the Kaggle arXiv metadata snapshot of 2026-09-12"},"code_links":[{"paper_slug":"longitudinal-latent-overall-toxicity-lotox","repo_url":"https://github.com/mspreafico/bo06-lotox","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}