{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/linear-mixed-effects-models-for-non-gaussian","title":"Linear Mixed-Effects Models for Non-Gaussian Repeated Measurement Data","arxiv_id":"1804.02592","date":"2018-04-07","proceeding":null,"authors":["Özgür Asar","David Bolin","Peter J. Diggle","Jonas Wallin"],"abstract":"We consider the analysis of continuous repeated measurement outcomes that are collected through time, also known as longitudinal data. A standard framework for analysing data of this kind is a linear Gaussian mixed-effects model within which the outcome variable can be decomposed into fixed-effects, time-invariant and time-varying random-effects, and measurement noise. We develop methodology that, for the first time, allows any combination of these stochastic components to be non-Gaussian, using multivariate Normal variance-mean mixtures. We estimate parameters by max- imum likelihood, implemented with a novel, computationally efficient stochastic gradient algorithm. We obtain standard error estimates by inverting the observed Fisher-information matrix, and obtain the predictive distributions for the random-effects in both filtering (conditioning on past and current data) and smoothing (conditioning on all data) contexts. To implement these procedures, we intro- duce an R package, ngme. We re-analyse two data-sets, from cystic fibrosis and nephrology research, that were previously analysed using Gaussian linear mixed effects models.","url_abs":"https://arxiv.org/abs/1804.02592v1","url_pdf":"https://arxiv.org/pdf/1804.02592v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"links_only","authors_date_abstract":"arXiv metadata, CC0 1.0 (https://info.arxiv.org/help/license), from the Kaggle arXiv metadata snapshot of 2026-09-12"},"code_links":[{"paper_slug":"linear-mixed-effects-models-for-non-gaussian","repo_url":"https://github.com/jinghuazhao/Mixed-Models","is_official":0,"mentioned_in_paper":0,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}