{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/lead-large-foundation-model-for-eeg-based","title":"LEAD: Large Foundation Model for EEG-Based Alzheimer's Disease Detection","arxiv_id":"2502.01678","date":"2025-02-02","proceeding":null,"authors":["Yihe Wang","Nan Huang","Nadia Mammone","Marco Cecchi","Xiang Zhang"],"abstract":"Electroencephalogram (EEG) provides a non-invasive, highly accessible, and cost-effective solution for Alzheimer's Disease (AD) detection. However, existing methods, whether based on manual feature extraction or deep learning, face two major challenges: the lack of large-scale datasets for robust feature learning and evaluation, and poor detection performance due to inter-subject variations. To address these challenges, we curate an EEG-AD corpus containing 813 subjects, which forms the world's largest EEG-AD dataset to the best of our knowledge. Using this unique dataset, we propose LEAD, the first large foundation model for EEG-based AD detection. Our method encompasses an entire pipeline, from data selection and preprocessing to self-supervised contrastive pretraining, fine-tuning, and key setups such as subject-independent evaluation and majority voting for subject-level detection. We pre-train the model on 11 EEG datasets and unified fine-tune it on 5 AD datasets. Our self-supervised pre-training design includes sample-level and subject-level contrasting to extract useful general EEG features. Fine-tuning is performed on 5 channel-aligned datasets together. The backbone encoder incorporates temporal and channel embeddings to capture features across both temporal and spatial dimensions. Our method demonstrates outstanding AD detection performance, achieving up to a 9.86% increase in F1 score at the sample-level and up to a 9.31% at the subject-level compared to state-of-the-art methods. The results of our model strongly confirm the effectiveness of contrastive pre-training and channel-aligned unified fine-tuning for addressing inter-subject variation. The source code is at https://github.com/DL4mHealth/LEAD.","url_abs":"https://arxiv.org/abs/2502.01678v2","url_pdf":"https://arxiv.org/pdf/2502.01678v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"lead-large-foundation-model-for-eeg-based","repo_url":"https://github.com/dl4mhealth/lead","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"pytorch","reach":{"status":"ok","spdx":"NOASSERTION"}}],"tasks":[{"task_slug":"alzheimer-s-disease-detection","task_name":"Alzheimer's Disease Detection"},{"task_slug":"eeg-1","task_name":"EEG"},{"task_slug":"eeg","task_name":"Electroencephalogram (EEG)"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":"https://app.syntology.ai/?focus=2502.01678","mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}