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The proposed approach is equipped with a novel Iterative Filter Adaptive Network (IFAN) that is specifically designed to handle spatially-varying and large defocus blur. For adaptively handling spatially-varying blur, IFAN predicts pixel-wise deblurring filters, which are applied to defocused features of an input image to generate deblurred features. For effectively managing large blur, IFAN models deblurring filters as stacks of small-sized separable filters. Predicted separable deblurring filters are applied to defocused features using a novel Iterative Adaptive Convolution (IAC) layer. We also propose a training scheme based on defocus disparity estimation and reblurring, which significantly boosts the deblurring quality. 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