{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/how-to-segment-in-3d-using-2d-models","title":"How to Segment in 3D Using 2D Models: Automated 3D Segmentation of Prostate Cancer Metastatic Lesions on PET Volumes Using Multi-angle Maximum Intensity Projections and Diffusion Models","arxiv_id":"2407.18555","date":"2024-07-26","proceeding":null,"authors":["Amirhosein Toosi","Sara Harsini","François Bénard","Carlos Uribe","Arman Rahmim"],"abstract":"Prostate specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) imaging provides a tremendously exciting frontier in visualization of prostate cancer (PCa) metastatic lesions. However, accurate segmentation of metastatic lesions is challenging due to low signal-to-noise ratios and variable sizes, shapes, and locations of the lesions. This study proposes a novel approach for automated segmentation of metastatic lesions in PSMA PET/CT 3D volumetric images using 2D denoising diffusion probabilistic models (DDPMs). Instead of 2D trans-axial slices or 3D volumes, the proposed approach segments the lesions on generated multi-angle maximum intensity projections (MA-MIPs) of the PSMA PET images, then obtains the final 3D segmentation masks from 3D ordered subset expectation maximization (OSEM) reconstruction of 2D MA-MIPs segmentations. Our proposed method achieved superior performance compared to state-of-the-art 3D segmentation approaches in terms of accuracy and robustness in detecting and segmenting small metastatic PCa lesions. The proposed method has significant potential as a tool for quantitative analysis of metastatic burden in PCa patients.","url_abs":"https://arxiv.org/abs/2407.18555v3","url_pdf":"https://arxiv.org/pdf/2407.18555v3.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"how-to-segment-in-3d-using-2d-models","repo_url":"https://github.com/Amirhosein2c/MIP-DDPM","is_official":1,"mentioned_in_paper":0,"mentioned_in_github":1,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"denoising","task_name":"Denoising"},{"task_slug":"segmentation","task_name":"Segmentation"}],"methods":[{"method_slug":"diffusion","method_name":"Diffusion"},{"method_slug":"pca","method_name":"PCA"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}