{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/how-adaptive-immunity-constrains-the","title":"How adaptive immunity constrains the composition and fate of large bacterial populations","arxiv_id":"1801.10086","date":"2018-07-17","proceeding":null,"authors":[],"abstract":"Features of the CRISPR-Cas system, in which bacteria integrate small segments\nof phage genome (spacers) into their DNA to neutralize future attacks, suggest\nthat its effect is not limited to individual bacteria but may control the fate\nand structure of whole populations. Emphasizing the population-level impact of\nthe CRISPR-Cas system, recent experiments show that some bacteria regulate\nCRISPR-associated genes via the quorum sensing (QS) pathway. Here we present a\nmodel that shows that from the highly stochastic dynamics of individual spacers\nunder QS control emerges a rank-abundance distribution of spacers that is\ntime-invariant, a surprising prediction that we test with dynamic\nspacer-tracking data from literature. This distribution depends on the state of\nthe competing phage-bacteria population, which due to QS-based regulation may\ncoexist in multiple stable states that vary significantly in their\nphage-to-bacterium ratio, a widely used ecological measure to characterize\nmicrobial systems.","url_abs":"http://arxiv.org/abs/1801.10086v2","url_pdf":"http://arxiv.org/pdf/1801.10086v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"how-adaptive-immunity-constrains-the","repo_url":"https://github.com/mbonsma/CRISPR-immunity","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}